https://www.cnbc.com/2019/07/02/researchers-used-crispr-technology-to-cure-hiv-in-living-mice.html

Researchers say they’re closer to finding cure for HIV after using CRISPR technology to eliminate disease in live mice for the first time

Using a combination of CRISPR gene-editing technology and a therapeutic treatment called LASER ART, scientists at Temple University and the University of Nebraska Medical Center said they erased HIV DNA from the genomes of animals in what they call an unprecedented study that was published Tuesday in the journal Nature Communications.

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

A bit of good news.

dv said:

https://www.cnbc.com/2019/07/02/researchers-used-crispr-technology-to-cure-hiv-in-living-mice.html

Researchers say they’re closer to finding cure for HIV after using CRISPR technology to eliminate disease in live mice for the first time

Using a combination of CRISPR gene-editing technology and a therapeutic treatment called LASER ART, scientists at Temple University and the University of Nebraska Medical Center said they erased HIV DNA from the genomes of animals in what they call an unprecedented study that was published Tuesday in the journal Nature Communications.

Sequential LASER ART and CRISPR Treatments Eliminate HIV-1 in a Subset of Infected Humanized Mice

“long-acting slow-effective release antiviral therapy (LASER ART)”

I wonder how long they had to work to come up with that acronym?

“more than 36.7 million people worldwide are infected with the human immunodeficiency virus type one (HIV-1) and >5000 individuals worldwide are newly infected each day. In the clinic, antiretroviral therapy (ART) restricts viral infection by stalling various steps of the viral life cycle.”

“ART cessation readily leads to viral reactivation and disease progression to acquired immunodeficiency syndrome (AIDS)”.

“elimination of HIV-1 infection in its infected human host is documented only in two individuals”. :-(

“hydrophobic lipophilic viral reservoir penetrating antiretroviral prodrugs”.

HIV was eliminated in 2 mice, was not eliminated in 5 mice on the same treatment. How do they actually get published with only two mice?