OK, knowing how much poik loves systematic reviews…I’ve never heard of this take on the goodness/badness of LDL cholesterol before. It’s British Medical Journal. Should be reliable.
https://bmjopen.bmj.com/content/6/6/e010401
And there’s a rabbit hole to go down there if you pursue the references in that paper. I don’t think I’ll do it right at the moment.
buffy said:
OK, knowing how much poik loves systematic reviews…I’ve never heard of this take on the goodness/badness of LDL cholesterol before. It’s British Medical Journal. Should be reliable.https://bmjopen.bmj.com/content/6/6/e010401
And there’s a rabbit hole to go down there if you pursue the references in that paper. I don’t think I’ll do it right at the moment.
My knowledge of medicine is extremely limited. Which cholesterol is supposed to be good cholesterol and which is supposed to be bad cholesterol?
> High LDL-C is inversely associated with mortality in most people over 60 years. This finding is inconsistent with the cholesterol hypothesis (ie, that cholesterol, particularly LDL-C, is inherently atherogenic). Since elderly people with high LDL-C live as long or longer than those with low LDL-C, our analysis provides reason to question the validity of the cholesterol hypothesis.
Are they trying to say that if your body survives with high LDL-C up to age 60 then you have to be healthier than normal?
HDL is the good one (I think of it as h for “happy” cholesterol). It strips out plaques from the LDL (the bad one) in your blood vessels.
I stand to be corrected if I’ve got that wrong.
I just went back to reading some of where this took me. I wasn’t actually looking for “The Cholesterol Controversy” – I didn’t even know it existed. But it’s fascinating and quite heated!
buffy said:
HDL is the good one (I think of it as h for “happy” cholesterol). It strips out plaques from the LDL (the bad one) in your blood vessels.I stand to be corrected if I’ve got that wrong.
“Some of the participants with high LDL-C may have started statin treatment during the observation period and, in this way, may have added a longer life to the group with high LDL-C and some of them may have started with a diet able to influence the risk of mortality.”
fkn derr…they could have removed all those patients but no…
Also, it’s now fairly well known that regardless of cholesterol levels, statins reduce the risk of all cause mortality in those with risk factors.
Is there any agreement that statins can cause cramping and muscle soreness?
sibeen said:
Is there any agreement that statins can cause cramping and muscle soreness?
Yea, but you could just be a sook.
poikilotherm said:
Also, it’s now fairly well known that regardless of cholesterol levels, statins reduce the risk of all cause mortality in those with risk factors.
So is that part of the inflammation theory? Which also seems to want a look in.
poikilotherm said:
sibeen said:
Is there any agreement that statins can cause cramping and muscle soreness?
Yea, but you could just be a sook.
:)
I actually had severe cramping before I knew it could be caused by statins. Changed the brand and dosage and big emprovement but I still think it effects me.
buffy said:
poikilotherm said:
Also, it’s now fairly well known that regardless of cholesterol levels, statins reduce the risk of all cause mortality in those with risk factors.
So is that part of the inflammation theory? Which also seems to want a look in.
Yea.
And then sometimes you get a laugh out of a paper:
“The trial was terminated early due to futility.”
The ACCELERATE trial
https://www.acc.org/latest-in-cardiology/clinical-trials/2016/03/29/22/34/accelerate
buffy said:
And then sometimes you get a laugh out of a paper:“The trial was terminated early due to futility.”
The ACCELERATE trial
https://www.acc.org/latest-in-cardiology/clinical-trials/2016/03/29/22/34/accelerate
Poor Roche, they try so hard.
poikilotherm said:
buffy said:
And then sometimes you get a laugh out of a paper:“The trial was terminated early due to futility.”
The ACCELERATE trial
https://www.acc.org/latest-in-cardiology/clinical-trials/2016/03/29/22/34/accelerate
Poor Roche, they try so hard.
there is a limit after which they breakdown i ‘spose.
poikilotherm said:
buffy said:
poikilotherm said:
Also, it’s now fairly well known that regardless of cholesterol levels, statins reduce the risk of all cause mortality in those with risk factors.
So is that part of the inflammation theory? Which also seems to want a look in.
Yea.
You know, probably 30 odd years ago a friend of mine who is a retired pathologist (he was still working then) told me that he felt medicine was going to eventually find that nearly everything is inflammation.
:)
poikilotherm said:
buffy said:
And then sometimes you get a laugh out of a paper:“The trial was terminated early due to futility.”
The ACCELERATE trial
https://www.acc.org/latest-in-cardiology/clinical-trials/2016/03/29/22/34/accelerate
Poor Roche, they try so hard.
Actually, I skipped a whole section in the latest Sci Am because it was “produced independently with support from Roche”. I’ll probably go back to it, it’s on AI and Digital Health “How artificial intelligence will change medicine”. But I’m not sure I’m interested enough.
ChrispenEvan said:
poikilotherm said:
buffy said:
And then sometimes you get a laugh out of a paper:“The trial was terminated early due to futility.”
The ACCELERATE trial
https://www.acc.org/latest-in-cardiology/clinical-trials/2016/03/29/22/34/accelerate
Poor Roche, they try so hard.
there is a limit after which they breakdown i ‘spose.
LOL
ChrispenEvan said:
poikilotherm said:
buffy said:
And then sometimes you get a laugh out of a paper:“The trial was terminated early due to futility.”
The ACCELERATE trial
https://www.acc.org/latest-in-cardiology/clinical-trials/2016/03/29/22/34/accelerate
Poor Roche, they try so hard.
there is a limit after which they breakdown i ‘spose.
Jaysus, that was erudite.
Come on, who stole Boris’s handle?
sibeen said:
ChrispenEvan said:
poikilotherm said:Poor Roche, they try so hard.
there is a limit after which they breakdown i ‘spose.
Jaysus, that was erudite.
Come on, who stole Boris’s handle?
see, this is what keeps you reading my posts, you may miss a good one…