Common, cheap, widely used Diabetes drug Metformin seems to remove the effect of diabetes on cognitive aging.

Radio National Health Report

(Link opens ABC web page)

Rule 303 said:

Common, cheap, widely used Diabetes drug Metformin seems to remove the effect of diabetes on cognitive aging.

Radio National Health Report

(Link opens ABC web page)

Very interesting.

What? Treating diabetes reduces the complications of diabetes? Well I never…

poikilotherm said:

What? Treating diabetes reduces the complications of diabetes? Well I never…

IKR? Maccas FTW!

poikilotherm said:

What? Treating diabetes reduces the complications of diabetes? Well I never…

Your cynicism is showing…

poikilotherm said:

What? Treating diabetes reduces the complications of diabetes? Well I never…

Boring results can still be important results. Sometimes the media’s obsession with “wow” headlines causes them to only publish unexpected results so perhaps this is there for balance.

Hey Poik, this reminds me of a question: Do beta blockers reduce cardiac output in exercise?

My understanding is they just reduce the effect of adrenaline, largely at rest, but do they change how the heart lifts to meet increased O2 demand?

Rule 303 said:

Hey Poik, this reminds me of a question: Do beta blockers reduce cardiac output in exercise?

My understanding is they just reduce the effect of adrenaline, largely at rest, but do they change how the heart lifts to meet increased O2 demand?

Yea. You’ll get short of breath as heart rate is limited by beta blockade.

dv said:

poikilotherm said:

What? Treating diabetes reduces the complications of diabetes? Well I never…

Boring results can still be important results. Sometimes the media’s obsession with “wow” headlines causes them to only publish unexpected results so perhaps this is there for balance.

Sif.

poikilotherm said:

Rule 303 said:

Hey Poik, this reminds me of a question: Do beta blockers reduce cardiac output in exercise?

My understanding is they just reduce the effect of adrenaline, largely at rest, but do they change how the heart lifts to meet increased O2 demand?

Yea. You’ll get short of breath as heart rate is limited by beta blockade.

Not me, but OK. Is there a known point where that happens? Either HR or %Max?

Rule 303 said:

poikilotherm said:

Rule 303 said:

Hey Poik, this reminds me of a question: Do beta blockers reduce cardiac output in exercise?

My understanding is they just reduce the effect of adrenaline, largely at rest, but do they change how the heart lifts to meet increased O2 demand?

Yea. You’ll get short of breath as heart rate is limited by beta blockade.

Not me, but OK. Is there a known point where that happens? Either HR or %Max?

Varies btw people. Need to do a stress test while blocked to work out where that is. Depends on beta blocker as well.

poikilotherm said:

Rule 303 said:

poikilotherm said:

Yea. You’ll get short of breath as heart rate is limited by beta blockade.

Not me, but OK. Is there a known point where that happens? Either HR or %Max?

Varies btw people. Need to do a stress test while blocked to work out where that is. Depends on beta blocker as well.

Hmmm. Must be difficult to establish a protocol for people who can’t sustain the work required to hit MHR.

Rule 303 said:

poikilotherm said:

Rule 303 said:

Not me, but OK. Is there a known point where that happens? Either HR or %Max?

Varies btw people. Need to do a stress test while blocked to work out where that is. Depends on beta blocker as well.

Hmmm. Must be difficult to establish a protocol for people who can’t sustain the work required to hit MHR.

If they’re that incompetent any exercise is beneficial …

poikilotherm said:

Rule 303 said:

poikilotherm said:

Varies btw people. Need to do a stress test while blocked to work out where that is. Depends on beta blocker as well.

Hmmm. Must be difficult to establish a protocol for people who can’t sustain the work required to hit MHR.

If they’re that incompetent any exercise is beneficial …

My experience of testing general public is that very few people could sustain the work required to hold their MHR for any more than a few seconds.