https://www.popsci.com/story/health/stress-causes-white-hair/
In 1902, the British Medical Journal reported an unusual case of rapid hair whitening.
A 22-year-old woman “witnessed a tragedy of a woman’s throat being cut and the victim falling dead at her feet,” according to a physician at the London Temperance Hospital. The next day, the right side of her pubic hair turned white, while the left half remained black.
This historic case study makes for a terribly weird (and rapid) example of an otherwise common occurrence: gray hairs seem to accumulate when we’re stressed. And it’s not just random violence that sends people’s pigment running—college exams, children, and work pressure appear to change our coloring, too. But for millennia, scholars have been relying mostly on anecdotal proof and intuition to rationalize this phenomenon.
To study this vexing relationship, the researchers created an elaborate animal model, which basically involved trying to turn black-haired rats white with lab-made stressors. They tried three different tactics: restraint stress, chronic unpredictable stress, and nociception-induced stress, which is caused by physical pain (or the threat of it). Each successfully turned the rat’s hair white. Perhaps unsurprisingly, nociception-induced stress, which the scientists stimulated by injecting the rats with resiniferatoxin, an analogue of the chili pepper compound capsaicin, worked best and fastest.