I think p_p will be interested to know that trials are underway now to see if a drop might work instead of the injections for diabetic macular oedema. It will be some time yet, but if this works out, it would be very good.

“The study aims to demonstrate safety and tolerability and an exploratory end point of efficacy through reduction in retinal thickness in a proportion of patients. “

So they are up to making sure it is safe and doesn’t do harm and also checking to see if enough of it gets to the retina to do anything.

More information here:

https://www.exonate.com/updates/exonate-announces-initiation-phase-ibii-clinical-t/

Don’t get too excited, it may still come to nothing. But someone is trying.

buffy said:

I think p_p will be interested to know that trials are underway now to see if a drop might work instead of the injections for diabetic macular oedema. It will be some time yet, but if this works out, it would be very good.

“The study aims to demonstrate safety and tolerability and an exploratory end point of efficacy through reduction in retinal thickness in a proportion of patients. “

So they are up to making sure it is safe and doesn’t do harm and also checking to see if enough of it gets to the retina to do anything.

More information here:

https://www.exonate.com/updates/exonate-announces-initiation-phase-ibii-clinical-t/

Don’t get too excited, it may still come to nothing. But someone is trying.

Too late. I’m already excited!

party_pants said:

buffy said:

I think p_p will be interested to know that trials are underway now to see if a drop might work instead of the injections for diabetic macular oedema. It will be some time yet, but if this works out, it would be very good.

“The study aims to demonstrate safety and tolerability and an exploratory end point of efficacy through reduction in retinal thickness in a proportion of patients. “

So they are up to making sure it is safe and doesn’t do harm and also checking to see if enough of it gets to the retina to do anything.

More information here:

https://www.exonate.com/updates/exonate-announces-initiation-phase-ibii-clinical-t/

Don’t get too excited, it may still come to nothing. But someone is trying.

Too late. I’m already excited!

:) where there’s a will…

buffy said:

I think p_p will be interested to know that trials are underway now to see if a drop might work instead of the injections for diabetic macular oedema. It will be some time yet, but if this works out, it would be very good.

“The study aims to demonstrate safety and tolerability and an exploratory end point of efficacy through reduction in retinal thickness in a proportion of patients. “

So they are up to making sure it is safe and doesn’t do harm and also checking to see if enough of it gets to the retina to do anything.

More information here:

https://www.exonate.com/updates/exonate-announces-initiation-phase-ibii-clinical-t/

Don’t get too excited, it may still come to nothing. But someone is trying.

> diabetic macular oedema

Yuk.

No drugs so far for oedema? That’s a shock.

mollwollfumble said:

buffy said:

I think p_p will be interested to know that trials are underway now to see if a drop might work instead of the injections for diabetic macular oedema. It will be some time yet, but if this works out, it would be very good.

“The study aims to demonstrate safety and tolerability and an exploratory end point of efficacy through reduction in retinal thickness in a proportion of patients. “

So they are up to making sure it is safe and doesn’t do harm and also checking to see if enough of it gets to the retina to do anything.

More information here:

https://www.exonate.com/updates/exonate-announces-initiation-phase-ibii-clinical-t/

Don’t get too excited, it may still come to nothing. But someone is trying.

> diabetic macular oedema

Yuk.

No drugs so far for oedema? That’s a shock.

Yes, anti VEGF drugs. But they have to be injected into the eye to get to the retina.

buffy said:

mollwollfumble said:

buffy said:

I think p_p will be interested to know that trials are underway now to see if a drop might work instead of the injections for diabetic macular oedema. It will be some time yet, but if this works out, it would be very good.

“The study aims to demonstrate safety and tolerability and an exploratory end point of efficacy through reduction in retinal thickness in a proportion of patients. “

So they are up to making sure it is safe and doesn’t do harm and also checking to see if enough of it gets to the retina to do anything.

More information here:

https://www.exonate.com/updates/exonate-announces-initiation-phase-ibii-clinical-t/

Don’t get too excited, it may still come to nothing. But someone is trying.

> diabetic macular oedema

Yuk.

No drugs so far for oedema? That’s a shock.

Yes, anti VEGF drugs. But they have to be injected into the eye to get to the retina.

VEGF?

“Vascular endothelial growth factor (VEGF) is a signalling protein that promotes the growth of new blood vessels.”

Hadn’t heard of this.

mollwollfumble said:

buffy said:

mollwollfumble said:

> diabetic macular oedema

Yuk.

No drugs so far for oedema? That’s a shock.

Yes, anti VEGF drugs. But they have to be injected into the eye to get to the retina.

VEGF?

“Vascular endothelial growth factor (VEGF) is a signalling protein that promotes the growth of new blood vessels.”

Hadn’t heard of this.

It’s a problem with compromised retina from macular degeneration or diabetic changes. If a part of the retina is deprived of oxygen, the VEGF starts screaming to make new blood vessels in there. Neovascularization – new blood vessels – are, in that situation, somewhat weak. You could say they are a rush job by the body. So, often they leak. Sometimes it’s actual bleeds, but more often it’s fluid through the thin blood vessel walls. Then you get oedema (excess fluid in the retina). The anti-VEGF is used to stop the body making these dodgy vessels.

In other parts of the body VEGF is useful in wound repair and stuff. But in the retina it’s dangerous to sight.

(I may have simplified things a bit…)

The good thing about the eye is if you put stuff directly in it, it doesn’t go anywhere, the drawback is you’ve got to put it directly in the eye.

Drops and ointments get absorbed and can lead to quite high systemic absorption and in some cases you don’t want that to happen.

poikilotherm said:

The good thing about the eye is if you put stuff directly in it, it doesn’t go anywhere, the drawback is you’ve got to put it directly in the eye.

Drops and ointments get absorbed and can lead to quite high systemic absorption and in some cases you don’t want that to happen.

I remember the beta blockers for glaucoma. At one stage we were even told to watch for signs of depression in patients.