Date: 14/09/2021 22:43:53
From: mollwollfumble
ID: 1790483
Subject: Your amygdala

An alternative to diets?

It was mentioned on TV a few days ago that the diet industry is the only industry that survives on a 98% failure rate. The same program mentioned the amydgala, deep in the brain.

An article in Nature magazine in 2020. Let’s see what is says.
https://sci-hub.st/https://www.nature.com/articles/s41366-020-0633-4

The amygdala is importantly involved in stress and obesity, but its role on weight change and diet-related stress remains unexplored among adolescents with excess weight. We aimed to examine the functional connectivity of the Central amygdala (CeA) and Basolateral amygdala (BLA) among adolescents, and to explore the longitudinal association between brain connectivity measures and diet-related cortisol and weight loss in adolescents with excess weight.

In excess weight individuals, the CeA regions showed higher functional connectivity with anterior portions, and lower connectivity with posterior portions of the cingulate cortex, while the left BLA regions showed lower connectivity with the dorsal caudate and angular gyrus.

Conclusion: The CeA-midbrain network might constitute an important brain pathway regulating weight change.

“ … neuroadaptions which alter the balance between hedonism and homeostasis”

“ We hypothesized that CeA and BLA regions will show higher connectivity with areas related to drives to eat and emotional valuation of food, but lower functional connectivity with areas related to internal awareness and eating behavior inhibition”.

Excessive weight was taken as >85th percentile for body mass index (BMI) in 14 to 19 year olds. Binge eaters, diabetics, and those with brain abmormalities detected by MRI were excluded from the study.

Cortisol (a stress hormone) was measured from their hair.

So what do you think? Could radiation treatment of the amygdala cure obesity in young people, giving them a longer healthy life?

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