As Omicron mutates wildly the virus shows first signs of convergent evolution
Unfortunately, it is converging on a variant that can evade current vaccines. This is apparently complicated by >>the body’s first exposure to a pathogen can leave a permanent immune imprint, or memory. This “original sin” can hinder our ability to fight that same pathogen if that pathogen begins to change its shape and become less recognizable. This is how the virus is mutating to evade our immune defenses.<<
>>several subvariants have already been detected with some of these mutations. Subvariants BQ.1.1 and XBB in particular were found to be the most immune evasive, escaping even Omicron-specific antibodies.<<
>>Cornelius Roemer, a viral evolution researcher based in Europe, has been at the forefront of chronicling the global growth of these new convergent variants. His monitoring has shown the more key RBD mutations in a subvariant, the faster its growth.
Roemer’s tracking suggests subvariants with four key RBD mutations may account for more than 30% of new viral samples up to the end of September. But add another two to three key RBD mutations and you see some extraordinary new subvariants (XBB, BQ.1.1 or BA.2.3.20) emerging and growing at rapid rates.<<
>>Marc Johnson describes the current emerging wave as more like a rising tide, and as all these subvariants converge on the same mutations we will see rising caseloads. And he says the rate of the virus mutating is “ridiculously fast.”<<
Lots more, plus an interesting read:
https://newatlas.com/science/omicron-mutates-convergent-evolution-original-antigenic-sin/