An item on the news about a new promising Alzheimer’s medicine.

https://www.abc.net.au/news/2023-07-18/alzheimers-disease-new-drugs-showing-promise/102612162

“The latest is called donanemab, with the findings of a global trial involving 1,700 patients presented at a major Alzheimer’s conference in The Netherlands. It was able to slow Alzheimer’s disease progression by 35 per cent in patients in the earliest stages of the disease. The donanemab study findings were similar to those of its predecessor lecanemab, sold under the brand name Leqembi. It reduced cognitive decline by 27 per cent in patients with early Alzheimer’s in a study published last year.”

“Leqembi is priced at about $US26,500 for a year’s supply of infusions every two weeks.”

“The drugs follow the groundbreaking but controversial release of Biogen’s Aducanumab in 2021. In June this year the Therapeutic Goods Administration found the drug did not meet its safety and efficacy requirements for approval in Australia.”
What do you think about it?

Try this quick quiz. What do the following have in common:
Esserine (a favourite poison of Agatha Christie), Nerve Gas, Organo-phosphate insecticide, and the most common Alzheimer’s medicine?

Answer. They’re all cholinesterase inhibitors. :-)

Fuck it, we’re going to head down to the grain silo to take some tablets right now.

“The clinical trial was able to demonstrate a slowing of disease progression, but it’s still not possible to say if that reaches a level that any nonspecialist observer would be able to notice outside of a controlled clinical trial. Just to be clear, by “nonspecialist observers”, I mean family members and acquaintances: would they be able to tell that a person was taking donanemab or not?

It’s still not clear, based on the changes in the rating scales, if they would, and that’s using the rating scale difference after 76 weeks of treatment. It’s important to remember that both the patients getting the antibody and the control patients getting placebo IVs deteriorated steadily over this whole period…”

poikilotherm said:

“The clinical trial was able to demonstrate a slowing of disease progression, but it’s still not possible to say if that reaches a level that any nonspecialist observer would be able to notice outside of a controlled clinical trial. Just to be clear, by “nonspecialist observers”, I mean family members and acquaintances: would they be able to tell that a person was taking donanemab or not?

It’s still not clear, based on the changes in the rating scales, if they would, and that’s using the rating scale difference after 76 weeks of treatment. It’s important to remember that both the patients getting the antibody and the control patients getting placebo IVs deteriorated steadily over this whole period…”

Does dementia progress evenly or does it do fits and starts? I’d have said fits and starts. But that is just a gut feeling about it.

buffy said:

poikilotherm said:

“The clinical trial was able to demonstrate a slowing of disease progression, but it’s still not possible to say if that reaches a level that any nonspecialist observer would be able to notice outside of a controlled clinical trial. Just to be clear, by “nonspecialist observers”, I mean family members and acquaintances: would they be able to tell that a person was taking donanemab or not?

It’s still not clear, based on the changes in the rating scales, if they would, and that’s using the rating scale difference after 76 weeks of treatment. It’s important to remember that both the patients getting the antibody and the control patients getting placebo IVs deteriorated steadily over this whole period…”

Does dementia progress evenly or does it do fits and starts? I’d have said fits and starts. But that is just a gut feeling about it.

Maybe there are lots of variations like with Microsoft.

buffy said:

poikilotherm said:

“The clinical trial was able to demonstrate a slowing of disease progression, but it’s still not possible to say if that reaches a level that any nonspecialist observer would be able to notice outside of a controlled clinical trial. Just to be clear, by “nonspecialist observers”, I mean family members and acquaintances: would they be able to tell that a person was taking donanemab or not?

It’s still not clear, based on the changes in the rating scales, if they would, and that’s using the rating scale difference after 76 weeks of treatment. It’s important to remember that both the patients getting the antibody and the control patients getting placebo IVs deteriorated steadily over this whole period…”

Does dementia progress evenly or does it do fits and starts? I’d have said fits and starts. But that is just a gut feeling about it.

The study looked at high tau protein and low, both deteriorated steadily , the high tau quicker than low.

I don’t know what evenly means, IME people get worse consistently until they die.

The Ross bro-in-law’s mother still recognises family members in photos but not necessarily in real life.

She spends much of the day with a teddy bear on her lap, deep in conversation with it.

1975 fashions.

Damn, must be going senile :(

Obviously meant for chat.

Bubblecar said:

Damn, must be going senile :(

Obviously meant for chat.

It came for PWM and now it’s come for you.

poikilotherm said:

buffy said:

poikilotherm said:

“The clinical trial was able to demonstrate a slowing of disease progression, but it’s still not possible to say if that reaches a level that any nonspecialist observer would be able to notice outside of a controlled clinical trial. Just to be clear, by “nonspecialist observers”, I mean family members and acquaintances: would they be able to tell that a person was taking donanemab or not?

It’s still not clear, based on the changes in the rating scales, if they would, and that’s using the rating scale difference after 76 weeks of treatment. It’s important to remember that both the patients getting the antibody and the control patients getting placebo IVs deteriorated steadily over this whole period…”

Does dementia progress evenly or does it do fits and starts? I’d have said fits and starts. But that is just a gut feeling about it.

The study looked at high tau protein and low, both deteriorated steadily , the high tau quicker than low.

I don’t know what evenly means, IME people get worse consistently until they die.

I couldn’t place the right word when I wrote the post. (I was in a hurry to go and watch the ABC thing on Aboriginal weapons) Some people I know just got steadily worse. Others got worse and then plateaued for a bit. And then fell further quickly and plateaued again. That is observing them in real life, not from doing testing or anything.

Bubblecar said:

Damn, must be going senile :(

Obviously meant for chat.

LOL!!!

Obviousman said:

Bubblecar said:

Damn, must be going senile :(

Obviously meant for chat.

LOL!!!

Grey hairs appering from all the cracks in the shielding.

buffy said:

poikilotherm said:

buffy said:

Does dementia progress evenly or does it do fits and starts? I’d have said fits and starts. But that is just a gut feeling about it.

The study looked at high tau protein and low, both deteriorated steadily , the high tau quicker than low.

I don’t know what evenly means, IME people get worse consistently until they die.

I couldn’t place the right word when I wrote the post. (I was in a hurry to go and watch the ABC thing on Aboriginal weapons) Some people I know just got steadily worse. Others got worse and then plateaued for a bit. And then fell further quickly and plateaued again. That is observing them in real life, not from doing testing or anything.

And there are good days and bad days, not to mention that you become de-sensitised to the decline as it becomes ‘normal’.

Obviousman said:

buffy said:

poikilotherm said:

The study looked at high tau protein and low, both deteriorated steadily , the high tau quicker than low.

I don’t know what evenly means, IME people get worse consistently until they die.

I couldn’t place the right word when I wrote the post. (I was in a hurry to go and watch the ABC thing on Aboriginal weapons) Some people I know just got steadily worse. Others got worse and then plateaued for a bit. And then fell further quickly and plateaued again. That is observing them in real life, not from doing testing or anything.

And there are good days and bad days, not to mention that you become de-sensitised to the decline as it becomes ‘normal’.

Unless others are watching, you are on your own on this journey,

roughbarked said:

Obviousman said:

buffy said:

I couldn’t place the right word when I wrote the post. (I was in a hurry to go and watch the ABC thing on Aboriginal weapons) Some people I know just got steadily worse. Others got worse and then plateaued for a bit. And then fell further quickly and plateaued again. That is observing them in real life, not from doing testing or anything.

And there are good days and bad days, not to mention that you become de-sensitised to the decline as it becomes ‘normal’.

Unless others are watching, you are on your own on this journey,

Yep. Since I am the son-in-law, I can maintain some detachment and watch impartially but my wife has to watch her father fade away.

> Does dementia progress evenly or does it do fits and starts? I’d have said fits and starts. But that is just a gut feeling about it.

I’m beginning to wonder that myself.

I had assumed that it progresses evenly, apart from dementia caused by strokes.

But my own loss of memory and brain power has seemed to progress in fits and starts.

Have a look at infrared light treatment

You blast your head with specific frequencies.

wookiemeister said:

Have a look at infrared light

Ya canna see it Jimmy.

Stand by

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608336/

and Laugh

https://www.europeanpharmaceuticalreview.com/news/184000/alzheimers-vaccine-granted-fda-fast-track-designation/

Out Loud.

AC Immune SA has received Fast Track designation from the US Food and Drug Administration (FDA) for its anti-amyloid beta (Abeta) active immunotherapy vaccine candidate for Alzheimer’s disease. This follows FDA clearance of the Investigational New Drug (IND) application, enabling expansion to the US of the ongoing Phase Ib/II ABATE study of ACI-24.060 in Alzheimer’s patients and individuals with Down’s syndrome.

SCIENCE said:

Stand by

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9608336/

and Laugh

https://www.europeanpharmaceuticalreview.com/news/184000/alzheimers-vaccine-granted-fda-fast-track-designation/

Out Loud.

AC Immune SA has received Fast Track designation from the US Food and Drug Administration (FDA) for its anti-amyloid beta (Abeta) active immunotherapy vaccine candidate for Alzheimer’s disease. This follows FDA clearance of the Investigational New Drug (IND) application, enabling expansion to the US of the ongoing Phase Ib/II ABATE study of ACI-24.060 in Alzheimer’s patients and individuals with Down’s syndrome.

Hopefully they can get that going

If we could vaccinate against alzheimers you’d save billions of dollars