From Burkes Back yard site re tomatoes:
Yellowing leaves?
As plants grow, the lower leaves go yellow and die. That is normal, so simply snip of any yellow leaves. However, if many leaves go yellow or the yellowing is accompanied by unhealthy looking blotches and spots, or if the plant wilts despite regular watering, the plant has probably contracted a bacterial, fungal or virus disease. Spraying with a copper-based fungicide such as Kocide or Fungus Fighter may help in some cases but usually the plant is doomed and ought be pulled out and disposed of. Don’t grow tomatoes in that spot again for at least two years.