As far as I have seen, Excel VBA Help is not especially helpful on the topic of the various “calculate” methods that are available. To make matters worse, sometimes the “calculate” buttons in the user interface don’t seem to work, leading me not to trust the lesser calculate methods and tending to go for the more extensive methods such as Application.CalculateFull and Application.CalculateFullRebuild. My question concerns the circumstances in which one should choose the various calculate methods, as well as the broader issue of whether or not to choose manual calculation mode. I should remark that for spreadsheets that are largely driven by spreadsheet functions (as distinct from being largely driven by VBA code), I make heavy use of the INDIRECT function.