While reading the current Skeptic magazine I came across a reference to this paper by James Watson:
http://rsob.royalsocietypublishing.org/content/3/1/120144.full#sec-22
A part of it, as a teaser:
22. Free-radical-destroying antioxidative nutritional supplements may have caused more cancers than they have prevented
For as long as I have been focused on the understanding and curing of cancer (I taught a course on Cancer at Harvard in the autumn of 1959), well-intentioned individuals have been consuming antioxidative nutritional supplements as cancer preventatives if not actual therapies. The past, most prominent scientific proponent of their value was the great Caltech chemist, Linus Pauling, who near the end of his illustrious career wrote a book with Ewan Cameron in 1979, Cancer and Vitamin C, about vitamin C’s great potential as an anti-cancer agent . At the time of his death from prostate cancer in 1994, at the age of 93, Linus was taking 12 g of vitamin C every day. In light of the recent data strongly hinting that much of late-stage cancer’s untreatability may arise from its possession of too many antioxidants, the time has come to seriously ask whether antioxidant use much more likely causes than prevents cancer.
It is quite a long and involved paper, but should be interesting. So far I have just skimmed it quickly. It seems to give the latest state of knowledge.
