Postpartum Depression Spans Generations, Animal Study Suggests

Oct. 8, 2013 — A recently published study suggests that exposure to social stress not only impairs a mother’s ability to care for her children but can also negatively impact her daughter’s ability to provide maternal care to future offspring.
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Researchers at the Cummings School of Veterinary Medicine at Tufts University conducted a transgenerational study with female rats, examining the behavioral and physiological changes in mothers exposed to chronic social stress early in life as a model for postpartum depression and anxiety.

A different male rat was placed in the cage of the first-generation mothers and their newly born pups for an hour a day for 15 days. Consistent with previous research, the lactating mother rats responded to the stress of the intruder with depressed maternal care, impaired lactation, and increased anxiety. The pups of these mothers were also exposed to the conflict between their mothers and the male intruders.

After reaching maturation, second-generation females were mated and compared to a control group where neither the mother nor the pups had been exposed to a male intruder. The second generation mothers that experienced the early life stress also displayed depressed maternal care, impaired lactation, and increased anxiety. There were also changes to hormone levels: an increase in the stress hormone corticosterone, and decreases in oxytocin, prolactin (important to both maternal behavior and lactation) and estradiol.

“The endocrine and behavioral data are consistent with what has been reported in studies of depressed human mothers. The potential with this animal model is that it can be used to study new preventive measures and treatments for postpartum depression and anxiety, and the adverse effects of these disorders on offspring,” said Benjamin C. Nephew, Ph.D., assistant professor in the Department of Biomedical Sciences at TCSVM and principal investigator of the study.

The study was published in the September issue of Hormones and Behavior.

“The chronic social stress model used in this study provides insight into how social stress affects both human and animal behavior in the areas of maternal care, anxiety and lactation, and provides a wealth of observations,” said Lindsay M. Carini, the study’s lead author.

Funding for the study came from the National Institute of Child Health and Human Development and the Tufts Clinical and Translational Science Institute.

This work builds off earlier Tufts research in the area of reproductive biology, which includes initial findings on the effects of chronic social stress on maternal behavior which was published in Stress by Nephew and Professor of Biomedical Sciences Robert Bridges, Nephew’s postdoctoral mentor at TCSVM.

http://www.sciencedaily.com/releases/2013/10/131008132914.htm

Interesting stuff… lots similar research on that site as well.

Interesting. Thanks.

It is interesting, probably an argument for being able to have some input and control of what company one keeps(rat or human, likely extends across and even between many species), the proximity to whatever or wheover other/s, maintaining (safe)operating space free of too many intrusions/impositions (‘risks’ loosely to generalize), which probably supports my argument that much of what is ‘social’ includes ‘privacy’.

I find it has some relationship to what humans might refer to as the ‘egalitarian ethic’, that of agreed powerfull norms etc, but them not being ‘imposed’ on any member of the moral community, that individuals have to agree to them and come around to them on their own terms or in their own way. To generalize I see this as ‘operating space’.

Many ‘social’ creatures need to manage proximity to others, for which I suppose being able to ignore others may be a feature, but for many the physical proximity is the way.

Of humans I note that perhaps being able to regulate phsyical proximity to others is restricted, so maybe we rely more on being able to ignore others, or rely more on others having a better developed manner of minding their own business.

I’d tend caution re reading too much into experiments of things being artificially places in confines/boxes, science has quite a history of drawing conclusions from such experiments, then the results go wild into the wider population for easy-think on the subject. Humans also have a history of considering environments external as being dominant determinants of behaviour, rather that from the perspective of internal environments (all that goes into homeostasis in the broadest sense for example).

transition said:

I’d tend caution re reading too much into experiments of things being artificially places in confines/boxes, science has quite a history of drawing conclusions from such experiments, then the results go wild into the wider population for easy-think on the subject. Humans also have a history of considering environments external as being dominant determinants of behaviour, rather that from the perspective of internal environments (all that goes into homeostasis in the broadest sense for example).

I agree!