Date: 16/11/2014 17:34:02
From: Bubblecar
ID: 628887
Subject: Should Woolly Mammoths Be Cloned?

Will woolly mammoths stride the Siberian plains once again? DNA samples from an exceptionally well preserved extinct Mammuthus, found in the snowy wastes of Siberia, have raised the prospect of cloning.

But scientists are divided about raising the species from the dead, 10,000 years after becoming extinct.

Russian scientists were amazed at the condition of the mammoth, found embedded in a chunk of ice on a remote Siberian island. The samples were so well preserved that fresh blood was found within muscle tissue.

The team used carbon dating techniques to reveal the animal had walked the Earth around 40,000 years ago and raised hopes that it could be cloned.

Nicknamed Buttercup, the adult female was discovered in May 2013. At 2.5 metres tall, she is not much larger than an Asian elephant. Incredibly, three legs, most of her body, some of her head and her trunk had survived. She was in her fifties when she became trapped in a peat bog and was eaten by predators, scientists believe.

A Channel 4 film, to be shown next weekend, follows Buttercup’s autopsy in Siberia, and the extraction of high-quality DNA and cells for future use by Sooam, a South Korean biotech company.

The Korean researchers hope to find a cell with a complete nucleus, containing an intact genome.

“We’re getting an unprecedented amount of access to mammoth samples through this collaboration,” said Insung Hwang, a geneticist at Sooam.

DNA has been distributed to multiple institutes for scientific purposes,” he added.

Dr Tori Herridge, a palaeobiologist based at the Natural History Museum in London said: “The guys from South Korea, who are collecting tissue for cloning, were excited because the better preserved the tissue, the greater their hopes were that there would be some intact DNA.”

However she warned that the dream of bringing the woolly mammoth back to life would be a cruel nightmare for their modern- day descendant, the elephant.

Dr Herridge, an expert in mammoth anatomy, said: “The most fundamental step and ethical concern with this kind of procedure is that you need to have an Asian elephant surrogate mum at some point; cloning a mammoth will require you to experiment on probably many, many Asian elephants.” She added: “The most important thing is how much we can learn without having to go down the route of cloning.”

Dr Herridge questioned “whether or not the justifications for cloning a mammoth are worth the suffering, the concerns of keeping an elephant in captivity, experimenting on her, making her go through a 22-month pregnancy, to potentially give birth to something which won’t live, or to carry something which could be damaging to her. And all of those aspects… I don’t think that they are worth it; the reasons just aren’t there.”

Full report: http://www.independent.co.uk/news/science/woolly-mammoth-cloning-war-scientists-divided-over-the-ethics-of-attempting-to-revive-extinct-mammal-9863415.html

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Date: 16/11/2014 20:09:32
From: party_pants
ID: 628968
Subject: re: Should Woolly Mammoths Be Cloned?

I’ll stick my neck out and say no to cloning a mammoth.

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Date: 17/11/2014 00:05:51
From: mollwollfumble
ID: 629042
Subject: re: Should Woolly Mammoths Be Cloned?

> Should Woolly Mammoths Be Cloned?

Hell yes. By the way, of nine mammoth species only one was woolly. It’s annoying that all the other eight mammoth species always get ignored in popular articles.

There have been a dozen or so elephant species that were driven to extinction by human beings. If humans have the chance to bring even one of them back then they definitely should. To do otherwise is tantamount to condoning the murder of an entire large vertebrate species.

> Will woolly mammoths stride the Siberian plains once again? DNA samples from an exceptionally well preserved extinct Mammuthus, found in the snowy wastes of Siberia, have raised the prospect of cloning.

I find this amusing. The first reports on this were entirely negative – although there was enough DNA to reconstruct mitochondrial DNA there was no chance of ever getting enough nuclear DNA to sequence. Any nuclear DNA that did survive was in minuscule chunks. “However, such ancient DNA is often fragmented and damaged, and studies to date have typically focused on short mitochondrial sequences, never yielding more than a fraction of a per cent of any nuclear genome.”

By the year 2008 enough of these tiny chunks existed to compare that fraction of a percent with elephant and mastadon information. So far as I can tell there’s been no significant progress since then. So cloning a woolly mammoth almost certainly isn’t possible.

The second barrier to such cloning is that mammoths are less closely related to elephants than African elephants are to Indian elephants, and those two are not inter-fertile. The physical similarity between African and Indian elephants is a result of convergent evolution of phenotype as the genome of each has strayed away from each other. The split between the mammoth and elephant occurred … perhaps 6 to 8 million years ago – far too far apart for the mammoth-elephant hybrid approach to work.

That makes mammoth reconstruction extremely difficult. I’d love to see it happen, but I don’t think it can.

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Date: 17/11/2014 00:12:18
From: kii
ID: 629044
Subject: re: Should Woolly Mammoths Be Cloned?

Apparently I am about to receive a parcel with large chunks of woolly mammoth tusk in it. From Alaska. I am slightly dubious.

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Date: 17/11/2014 00:14:20
From: party_pants
ID: 629046
Subject: re: Should Woolly Mammoths Be Cloned?

kii said:


Apparently I am about to receive a parcel with large chunks of woolly mammoth tusk in it. From Alaska. I am slightly dubious.

It might be mastodon rather than woolly mammoth.

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Date: 17/11/2014 00:20:59
From: kii
ID: 629049
Subject: re: Should Woolly Mammoths Be Cloned?

Either way, I have mixed feelings about it. As it is a well-intentioned gift, I will accept it with grace. The guy is expecting me to make jewellery from it. We will see.

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Date: 18/11/2014 15:30:53
From: dv
ID: 629898
Subject: re: Should Woolly Mammoths Be Cloned?

I would say hell yes.

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Date: 18/11/2014 15:55:31
From: Bubblecar
ID: 629905
Subject: re: Should Woolly Mammoths Be Cloned?

dv said:


I would say hell yes.

How many?

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Date: 18/11/2014 15:59:15
From: dv
ID: 629907
Subject: re: Should Woolly Mammoths Be Cloned?

Bubblecar said:


dv said:

I would say hell yes.

How many?

Hundreds, thousands.

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Date: 18/11/2014 16:00:00
From: Bubblecar
ID: 629909
Subject: re: Should Woolly Mammoths Be Cloned?

dv said:


Bubblecar said:

dv said:

I would say hell yes.

How many?

Hundreds, thousands.

How would you feed them?

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Date: 18/11/2014 16:02:21
From: dv
ID: 629911
Subject: re: Should Woolly Mammoths Be Cloned?

Bubblecar said:


dv said:

Bubblecar said:

How many?

Hundreds, thousands.

How would you feed them?

I’m rather hoping they’d feed themselves, on grass, given that they were grazing animals.

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