Interesting study on the effectiveness of phenylephrine vs sudafed

Phenylephrine was not significantly different from placebo in the primary end point, mean change in nasal congestion score at more than 6 hours (P = .56), whereas pseudoephedrine was significantly more effective than both placebo (P < .01) and phenylephrine (P = .01). Phase 1 results showed a difference between phenylephrine and placebo that was 64% of the difference between pseudoephedrine and placebo, substantially greater than the 17% difference observed for all phases. Carryover bias due to patient recall of the pseudoephedrine effect may have influenced these results. Rhinomanometry and peak nasal inspiratory flow results were consistent with these data. Neither phenylephrine nor pseudoephedrine had an effect on the nonnasal symptoms. No adverse events were reported in this study.
CONCLUSIONS:
During a 6-hour observation period, a single dose of pseudoephedrine but not phenylephrine resulted in significant improvement in measures of nasal congestion. Neither phenylephrine nor pseudoephedrine had an effect on nonnasal symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/19230461

Dropbear said:

Interesting study on the effectiveness of phenylephrine vs sudafed

Phenylephrine was not significantly different from placebo in the primary end point, mean change in nasal congestion score at more than 6 hours (P = .56), whereas pseudoephedrine was significantly more effective than both placebo (P < .01) and phenylephrine (P = .01). Phase 1 results showed a difference between phenylephrine and placebo that was 64% of the difference between pseudoephedrine and placebo, substantially greater than the 17% difference observed for all phases. Carryover bias due to patient recall of the pseudoephedrine effect may have influenced these results. Rhinomanometry and peak nasal inspiratory flow results were consistent with these data. Neither phenylephrine nor pseudoephedrine had an effect on the nonnasal symptoms. No adverse events were reported in this study.
CONCLUSIONS:
During a 6-hour observation period, a single dose of pseudoephedrine but not phenylephrine resulted in significant improvement in measures of nasal congestion. Neither phenylephrine nor pseudoephedrine had an effect on nonnasal symptoms.

http://www.ncbi.nlm.nih.gov/pubmed/19230461

“Vienna Challenge Chamber”

Sounds like something PWM would have at the redoubt.

I wonder if Phenylephrine was known to be less effective but it was used as druggies couldn’t use it to make meth.

poikilotherm said:

“Vienna Challenge Chamber”

Sounds like something PWM would have at the redoubt.

People against Andre Rieu

Cymek said:

I wonder if Phenylephrine was known to be less effective

yep

poik, do you get people giving you drama over this? or is it just me ? ;)

Dropbear said:

poik, do you get people giving you drama over this? or is it just me ? ;)

why? have you given poik drama about this before?

Dropbear said:

poik, do you get people giving you drama over this? or is it just me ? ;)

Yea…bit im that dodgy pharmacist that gives people pseudo instead, the profit margin is bigger ;)

poikilotherm said:

Dropbear said:

poik, do you get people giving you drama over this? or is it just me ? ;)

Yea…bit im that dodgy pharmacist that gives people pseudo instead, the profit margin is bigger ;)

You have to take names don’t you and a signed contact giving you their first born

Cymek said:

poikilotherm said:

Dropbear said:

poik, do you get people giving you drama over this? or is it just me ? ;)

Yea…bit im that dodgy pharmacist that gives people pseudo instead, the profit margin is bigger ;)

You have to take names don’t you and a signed contact giving you their first born

We are meant to take the newborn but I don’t want that kind of hassle.

Cymek said:

poikilotherm said:

Dropbear said:

poik, do you get people giving you drama over this? or is it just me ? ;)

Yea…bit im that dodgy pharmacist that gives people pseudo instead, the profit margin is bigger ;)

You have to take names don’t you and a signed contact giving you their first born

Name: Papa Smurf

Do you keep significant quantities of pseudepherine in stock?
Its restriction doesn’t seem to have slowed down meth manufacturing

Cymek said:

Do you keep significant quantities of pseudepherine in stock?
Its restriction doesn’t seem to have slowed down meth manufacturing

No. Get robbed too often if u do.

There’s been multiple studies that have shown this. It’s hardly news.

I couldn’t understand why my local pharmacy was selling it. Then I found the salt lamps and homoeopathy section as well as the weekly in store naturopath.

Teleost said:

There’s been multiple studies that have shown this. It’s hardly news.

I couldn’t understand why my local pharmacy was selling it. Then I found the salt lamps and homoeopathy section as well as the weekly in store naturopath.

except there are also multiple studies that state it works too…

http://dx.doi.org/10.1016/j.clinthera.2007.05.021

poikilotherm said:

Teleost said:

There’s been multiple studies that have shown this. It’s hardly news.

I couldn’t understand why my local pharmacy was selling it. Then I found the salt lamps and homoeopathy section as well as the weekly in store naturopath.

except there are also multiple studies that state it works too…

http://dx.doi.org/10.1016/j.clinthera.2007.05.021

This science stuff is shit .. They can’t agree on anything

Dropbear said:

poikilotherm said:

Teleost said:

There’s been multiple studies that have shown this. It’s hardly news.

I couldn’t understand why my local pharmacy was selling it. Then I found the salt lamps and homoeopathy section as well as the weekly in store naturopath.

except there are also multiple studies that state it works too…

http://dx.doi.org/10.1016/j.clinthera.2007.05.021

This science stuff is shit .. They can’t agree on anything

IKR.

poor bastards in that study…

“Phenylephrine as an alternative to cocaine”

poikilotherm said:

poor bastards in that study…

“Phenylephrine as an alternative to cocaine”

I’d like to be in the control group, sir

Dropbear said:

poikilotherm said:

poor bastards in that study…

“Phenylephrine as an alternative to cocaine”

I’d like to be in the control group, sir

And old boilers as an alternative to supermodels

Cymek said:

Dropbear said:

poikilotherm said:

poor bastards in that study…

“Phenylephrine as an alternative to cocaine”

I’d like to be in the control group, sir

And old boilers as an alternative to supermodels

PWM finally does science ;)

Dropbear said:

poikilotherm said:

poor bastards in that study…

“Phenylephrine as an alternative to cocaine”

I’d like to be in the control group, sir

is Phenylephrine as easy to snort of a SM butt as cocaine?

stumpy_seahorse said:

Dropbear said:

poikilotherm said:

poor bastards in that study…

“Phenylephrine as an alternative to cocaine”

I’d like to be in the control group, sir

is Phenylephrine as easy to snort of a SM butt as cocaine?

You don’t need to hand over your drivers license .. That’s one thing

I only take wookiemeisterphrine

Cymek said:

I wonder if Phenylephrine was known to be less effective but it was used as druggies couldn’t use it to make meth.

Agree. I’m actually startled that the FDA (etc.) passed it as a replacement. In order to be approved as a commercial drug any proposed drug has to be proved to be not just better than a placebo but also better than other commercial drugs. Phenylephrine ought never to have passed. That last restriction imposed by the FDA (etc.) I happen to find to be immoral and exceptionally short-sighted, because it doesn’t take into account changes in individual tolerance with time.

> phenylephrine vs sudafed

Badly stated. ¿You do know that off-the-shelf Sudafed is phenylephrine these days?

mollwollfumble said:

> phenylephrine vs sudafed

Badly stated. ¿You do know that off-the-shelf Sudafed is phenylephrine these days?

Sudafed is the common name for psuedo

No such thing as the FDA here…

poikilotherm said:

No such thing as the FDA here…

Hence the “etc.” In Australia it’s TGA isn’t it?

mollwollfumble said:

poikilotherm said:

No such thing as the FDA here…

Hence the “etc.” In Australia it’s TGA isn’t it?

yep, only requirements are for safety and efficacy v placebo. Non-inferiority studies not required.