Delta-V
Delta-V of a particular rocketry operation is the accumulated instantaneous change in speed wrt an inertial frame: it does not represent the actual change in speed, necessarily. For instance, an object in low earth orbit (LEO) is moving at around 7700 m/s, the object on the ground is moving at around 400 m/s, but to get to low earth orbit you need a delta-V of between 9000 and 10000 m/s, depending on the delivery system.
Per the Tsiolkovsky equation, for a specific impulse (roughly equivalent to given rocket exhaust speed) the wet to dry weight ratio (ie fueled to depleted) changes exponentially with delta-V. e.g. if you double the delta-V, you can basically expect to square the wet to dry ratio.
Considering only conventional chemical rockets for now: different propellents will have different specific impulses. Among the affordable ones, H2/O2 has the highest specific impulse at about 4500 m/s but H2 leaks like a sieve so you can only use it for launch or in the very early part of a mission. (Methane/O2 is not bad on 3000 m/s, kero is okay at 2900 m/s, and there are advantages to using liquid fuels.) For rocketry stages that will be fired after months or years, you are going to want something that has a highish boiling point, without tiny molecules that can leak through solid steel, won’t ice up so much, and that will ignite spontaneously when the oxidiser and reducer are mixed: unsymmetrical dimethylhydrazine and nitrogen tetroxide are a popular pair.
A fly-by will require less total mission delta-V than an orbital mission, because an orbital mission will require a major orbital insertion burn at the target (though this can lowered if aerobraking is used.) A landing mission to an airless orb will take even more delta-V, one to a airy place could be less if you can rely solely on aerobraking. There are a lot of permutations.
Bottom line: for a given size of parcel to deliver to a solar system target, if you can reduce the amount of propulsive delta-V required, you can reduce the required LEO-mass (and hence choose a cheaper launcher), or alternatively you can stick to the same launcher and deliver a better parcel to the target. This is why reducing the total mission delta-V is good.
Transfer orbits
Your basic minimum energy transfer from one planet to another is a Hohmann transfer. This is a reasonable option for inner solar system targets.
A Hohmann throw to Mars takes about eight months.
To Venus, about five months.
Mercury, about three months.
Jupiter, 33 months.
Often, though, you want to get there faster, and you can spend a bit more delta-V, which means either a bigger launcher or a smaller parcel. But what you can’t do is say that you are happy to take longer and reduce the delta-V, if you’re using a direct transfer.
Fortunately, it is possible to get some free delta-V using “gravity assists” or gravitational slingshot.
Mariner 10 (launched 1973) was the first mission ever to use a GA, based on the orbital mechanics plans of Bepi Colombo, the Italian mathematician. It made a single pass of Venus to give a kick down to the first of a series of Mercury flybys. MESSENGER, thirty years later, used a single Earth flyby and two Venus flybys, then three Mercury flybys in order to drop enough speed to eventually go into Mercury orbital insertion. So far, then, all missions to Mercury have been “via” Venus, and the 2017 ESA mission (named BepiColombo) will also involve multiple Earth-Venus-Mercury flybys.
Venus flybys have also been used to save delta-V in going to Jupiter. It adds years to the target arrival delay but the delta-V saving greatly improves the mass of equipment that can get to target for a given launch hardware.
Also, every single thing that has been sent beyond Jupiter has used a Jupiter flyby.
-Pioneer 10 (Jupiter)
-Pioneer 11 (Jupiter, Saturn)
-Voyager 1 (Jupiter, Saturn)
-Voyager 2 (Jupiter, Saturn, Uranus, Neptune)
-Ulysses (which used a Jupiter flyby to reach a high orbit out of the ecliptic in order to view the sun’s pole)
-Galileo (Venus, Earth, Earth, Jupiter)
-Cassini (Venus, Venus, Earth, Jupiter, Saturn) which is the only probe so far to use inner solar system GA AND a Jupiter GA to reach another target)
-New Horizon (Jupiter, Pluto)
-Juno (upcoming) (Earth, Jupiter)
Cassini’s route may seem unduly circuitous: it took fully seven years to reach Saturn. But for a single Titan IV launch they managed to send the most massive and complicated interplanetary probe (and lander!) ever commissioned by NASA. It arrived at Saturn with a mass of 5.6 tonnes (including 3.1 tonnes of propellent for the orbit insertion burns: its mass was 2.5 tonnes after orbital insertion) and 13 separate science and imaging instruments. It would not have been possible to deliver such a craft without the multiple gravitational assists.
If you’re patient, and you can get your craft to Venus, then you can get it to Jupiter: if you can get it Jupiter, then you can get it anywhere.