Anyone here tried this stuff? It’s a “wakefulness-promoting agent” that is apparently widely used by university students and others as a cognitive enhancer, said to improve attention, memory and general application to difficult tasks. It’s also being used by the military in place of amphetamines. Relatively few side effects have been reported.

https://en.wikipedia.org/wiki/Modafinil

Bubblecar said:

Anyone here tried this stuff? It’s a “wakefulness-promoting agent” that is apparently widely used by university students and others as a cognitive enhancer, said to improve attention, memory and general application to difficult tasks. It’s also being used by the military in place of amphetamines. Relatively few side effects have been reported.

https://en.wikipedia.org/wiki/Modafinil

In 2007, the FDA ordered Cephalon to modify the Provigil leaflet in bold-face print of several serious and potentially fatal conditions attributed to modafinil use, including toxic epidermal necrolysis (TEN), DRESS syndrome, and Stevens-Johnson syndrome (SJS).

The long term safety and effectiveness of modafinil have not been determined.

Modafinil may have an adverse effect on hormonal contraceptives, lasting for a month after cessation of dosage.

Modafinil may induce severe dermatologic reactions requiring hospitalization. From the date of initial marketing, December 1998, to January 30, 2007, FDA received six cases of severe cutaneous adverse reactions associated with modafinil, including erythema multiforme (EM), SJS, TEN, and DRESS involving adult and pediatric patients. The FDA issued a relevant alert. In the same alert, the FDA also noted that angioedema and multi-organ hypersensitivity reactions have also been reported in postmarketing experience.

https://en.wikipedia.org/wiki/Modafinil

I’m no expert, but my understanding is that these serious side effects are extremely rare.

Bubblecar said:

I’m no expert, but my understanding is that these serious side effects are extremely rare.

>>Modafinil is a wakefulness-promoting agent (or eugeroic) used for treatment of narcolepsy, shift work sleep disorder, and excessive daytime sleepiness associated with obstructive sleep apnea.

Because of the risk for development of skin or hypersensitivity reactions and neuropsychiatric disorders, the European Medicines Agency has recommended that new patient prescriptions should only be to treat sleepiness associated with narcolepsy.[7<<

Wiki

That Wiki entry doesn’t seem to have been updated since this systematic review was published this month:

Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review

Abstract

Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels, and indirectly decreases cerebral gamma-amino-butrytic acid levels. In addition to its approved use treating excessive somnolence, modafinil is thought to be used widely off-prescription for cognitive enhancement. However, despite this popularity, there has been little consensus on the extent and nature of the cognitive effects of modafinil in healthy, non-sleep-deprived humans. This problem is compounded by methodological discrepancies within the literature, and reliance on psychometric tests designed to detect cognitive effects in ill rather than healthy populations. In order to provide an up-to-date systematic evaluation that addresses these concerns, we searched MEDLINE with the terms “modafinil” and “cognitive”, and reviewed all resultant primary studies in English from January 1990 until December 2014 investigating the cognitive actions of modafinil in healthy non-sleep-deprived humans. We found that whilst most studies employing basic testing paradigms show that modafinil intake enhances executive function, only half show improvements in attention and learning and memory, and a few even report impairments in divergent creative thinking. In contrast, when more complex assessments are used, modafinil appears to consistently engender enhancement of attention, executive functions, and learning. Importantly, we did not observe any preponderances for side effects or mood changes. Finally, in light of the methodological discrepancies encountered within this literature, we conclude with a series of recommendations on how to optimally detect valid, robust, and consistent effects in healthy populations that should aid future assessment of neuroenhancement.

http://www.europeanneuropsychopharmacology.com/article/S0924-977×(15)00249-7/abstract?cc=y=

In need of some legal uppers Mr car?

poikilotherm said:

In need of some legal uppers Mr car?

Might be a help at times :)

Bubblecar said:

That Wiki entry doesn’t seem to have been updated since this systematic review was published this month:

Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review

Abstract

Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels, and indirectly decreases cerebral gamma-amino-butrytic acid levels. In addition to its approved use treating excessive somnolence, modafinil is thought to be used widely off-prescription for cognitive enhancement. However, despite this popularity, there has been little consensus on the extent and nature of the cognitive effects of modafinil in healthy, non-sleep-deprived humans. This problem is compounded by methodological discrepancies within the literature, and reliance on psychometric tests designed to detect cognitive effects in ill rather than healthy populations. In order to provide an up-to-date systematic evaluation that addresses these concerns, we searched MEDLINE with the terms “modafinil” and “cognitive”, and reviewed all resultant primary studies in English from January 1990 until December 2014 investigating the cognitive actions of modafinil in healthy non-sleep-deprived humans. We found that whilst most studies employing basic testing paradigms show that modafinil intake enhances executive function, only half show improvements in attention and learning and memory, and a few even report impairments in divergent creative thinking. In contrast, when more complex assessments are used, modafinil appears to consistently engender enhancement of attention, executive functions, and learning. Importantly, we did not observe any preponderances for side effects or mood changes. Finally, in light of the methodological discrepancies encountered within this literature, we conclude with a series of recommendations on how to optimally detect valid, robust, and consistent effects in healthy populations that should aid future assessment of neuroenhancement.

http://www.europeanneuropsychopharmacology.com/article/S0924-977×(15)00249-7/abstract?cc=y=

Go and live dangerously then, and see how many people you make pace up and down.

PermeateFree said:

Bubblecar said:

That Wiki entry doesn’t seem to have been updated since this systematic review was published this month:

Modafinil for cognitive neuroenhancement in healthy non-sleep-deprived subjects: a systematic review

Abstract

Modafinil is an FDA-approved eugeroic that directly increases cortical catecholamine levels, indirectly upregulates cerebral serotonin, glutamate, orexin, and histamine levels, and indirectly decreases cerebral gamma-amino-butrytic acid levels. In addition to its approved use treating excessive somnolence, modafinil is thought to be used widely off-prescription for cognitive enhancement. However, despite this popularity, there has been little consensus on the extent and nature of the cognitive effects of modafinil in healthy, non-sleep-deprived humans. This problem is compounded by methodological discrepancies within the literature, and reliance on psychometric tests designed to detect cognitive effects in ill rather than healthy populations. In order to provide an up-to-date systematic evaluation that addresses these concerns, we searched MEDLINE with the terms “modafinil” and “cognitive”, and reviewed all resultant primary studies in English from January 1990 until December 2014 investigating the cognitive actions of modafinil in healthy non-sleep-deprived humans. We found that whilst most studies employing basic testing paradigms show that modafinil intake enhances executive function, only half show improvements in attention and learning and memory, and a few even report impairments in divergent creative thinking. In contrast, when more complex assessments are used, modafinil appears to consistently engender enhancement of attention, executive functions, and learning. Importantly, we did not observe any preponderances for side effects or mood changes. Finally, in light of the methodological discrepancies encountered within this literature, we conclude with a series of recommendations on how to optimally detect valid, robust, and consistent effects in healthy populations that should aid future assessment of neuroenhancement.

http://www.europeanneuropsychopharmacology.com/article/S0924-977×(15)00249-7/abstract?cc=y=

Go and live dangerously then, and see how many people you make pace up and down.

You know there is is thing called dosage

and just a reminder about dosage is that it can be a very tiny amount or perhaps a little bit more or perhaps a lager amount

thing is with dosage is that it is variable, that is a very important aspect of dosage

is that the dosage can be changed, as in the amount can be altered, if you start with a small amount and consume it,

you will end up with trace amounts in your body, trace amounts happen because of the way the drug is delivered into your body

some medications are more sophisticated in that they will release trace amount more slowly than some other drugs

consider vitamin capsules , most of these vitamins pass right through your body through your urine, leaving only trace amounts that the body will use

with alcohol if one was to have just half a glass of wine then is that person drunk?

with cannabis if one was to smoke a small amount say not any larger than a half a match head, is that person stoned?

so there is is thing called dosage and there are other aspects of drugs like purity, and how clean it is etc

street drugs are usually not clean, while chemist drugs are clean

etc

paces up and down

what dosage are you going to take Bubblecar

>what dosage are you going to take Bubblecar

I’m not necessarily going to take any. Just looking into it at this stage.

Quite expensive Mr car.

Bubblecar said:

poikilotherm said:

In need of some legal uppers Mr car?

Might be a help at times :)

So you can spend more time cooking midnight suppers?

I had circadian rhythm disorder for a while. I wonder what was prescribed, I’ll check. Oh well, whatever it was, it didn’t work.