From links
> low-intensity focused ultrasound pulsation. The researchers targeted the thalamus with low-intensity focused ultrasound pulsation. The treatment made use of sonic stimulation to stir up the neurons in the thalamus—the brain’s focal center for processing information.
> The 1990s saw an increased interest in the use of focussed ultrasound (FUS) for several practical applications: use of high intensity HIFU for ablation, stroke thrombolysis, and peripheral nerve blocking. Interest increased with the discovery that FUS can be used also to open the blood brain barrier (BBB), and deliver drugs to the brain focally. Disrupting the BBB with US could be done with or without use of a contrast agent that enhances the cavitations at lower power of ultrasonic application. Disruption of the BBB at lower powers was usually reversible, and accompanied only by minimal evidence for apoptosis and ischemia. Although disruption of the BBB opens another chapter in direct drug delivery to specific areas within the brain.
> Shorter duration pulses of low intensity US seem to activate, whereas longer pulses seem to inhibit, the amplitude and velocity of nerve action potentials. Low-Intensity Focused Ultrasound Pulsation (LIFUP).
> That device, about the size of a coffee cup saucer, creates a small sphere of acoustic energy that can be aimed at different regions of the brain to excite brain tissue. For the new study, researchers placed it by the side of the man’s head and activated it 10 times for 30 seconds each, in a 10-minute period. It emits only a small amount of energy — less than a conventional Doppler ultrasound.
Picture of device focussed on the thalamus inside the brain.
