http://www.bbc.com/earth/story/20150622-can-anything-live-forever
Most animals eventually get old and die. But a few lucky species don’t seem to feel the weight of time, and just keep going and going
“ By Colin Barras
19 June 2015
Immortality can be a curse rather than a blessing – as Tithonus learned to his cost.
This mythical Trojan prince was so handsome that he bewitched Eos, the goddess of dawn. She successfully petitioned Zeus to grant Tithonus immortality so she could be with him forever.
But Zeus interpreted her request literally. Tithonus didn’t die, but he did age. He lost his good looks and his faculties, and Eos lost her interest. She eventually shut him away in a room where he babbles endlessly.
It’s just a story. But as is often the case, truth turns out to be stranger than fiction. Plenty of species really are technically immortal. And unlike Tithonus, many are eternally youthful to boot.”
What we’re talking about here is “biological immortality”, although many biologists would probably rather we didn’t use the phrase.
Biologically immortal organisms do die, but they don’t seem to age
“Immortal really means you don’t die at all, which is stupid,” says Thomas Bosch at the University of Kiel, Germany.
Paradoxical though it might seem, biologically immortal organisms are definitely mortal. They can be killed by a predator, a disease, or a catastrophic change in the environment such as an erupting volcano. But unlike humans, they rarely die simply because they get old.
To put it another way, biologically immortal organisms do die, but they don’t seem to age. They’re basically the exact opposite of Tithonus.
he bristlecone pine is a good example. Some of these North American trees are astonishingly old. They began growing 5000 years ago: about the time the real city of Troy was founded in what is now Turkey.
An old bristlecone pine looks old
As far as external appearances go, the years have been about as kind to the bristlecone pines as they will have been to Tithonus.
“The trees are pretty beaten up,” says Howard Thomas at Aberystwyth University in the UK. “They get struck by lightning, weighed down by heavy snow fall, branches snap off.”
In other words, an old bristlecone pine looks old. But look more closely and it’s a different story.
A study published in 2001 compared pollen and seeds from bristlecone pines of various ages up to 4700 years, and found no significant increase in mutation rates with age. What’s more, the vascular tissue functioned just as well in ancient trees as in juveniles.
The stem cells can apparently remain youthful and vigorous for millennia
Old trees are weather-beaten and gnarled, but at the cellular level they appear to be as youthful as they were when Troy was being built. Their tissues don’t seem to be withered by such vast expanses of time.
No one really knows how the bristlecone pine does it. Their longevity isn’t as well studied as you might expect. But Thomas thinks it probably comes down to a special property of the trees’ “meristems”.
These are bits of the roots and shoots that are home to populations of stem cells, which generate new growth. The stem cells can apparently remain youthful and vigorous for millennia.
“You do get mutations, things can go wrong,” says Thomas. “But like a bacterial culture, the non-mutated cells appear to outperform the damaged ones.”
There’s another possibility, says Lieven De Veylder at Ghent University in Belgium. He thinks a key factor might be a small population of cells in plant meristems called the “quiescent centre”.
These secret tricks of the meristem don’t help most plants achieve immortality
Here, cells divide at a much reduced rate, and that might suppress division of the meristem stem cells too. That could be useful, because every time a cell divides it runs the risk of incorporating a dangerous mutation into its DNA. “Keeping a subpopulation of stem cells that divide only infrequently might be a way to keep a close-to-perfect ‘back-up’ genome,” says De Veylder.
In 2013 his team identified a protein that seems to control activity in the quiescent centre of a plant called Arabidopsis. Similar proteins might help plants like the bristlecone pine avoid cellular ageing, allowing some of them to live for thousands of years.
However, these secret tricks of the meristem don’t help most plants achieve immortality. That’s because they live too fast.
A wave of senescence can overrun the behaviour of the meristem, and you have an annual or biennial plant,” says Thomas. In essence, the cells of plants like Arabidopsis work and divide so quickly, their organs burn out before the meristem can replenish the damaged tissue.
Ming the mollusc is the oldest verified solitary animal on record
By contrast, the biologically immortal plants live at a more measured pace. “Overlaying the meristem activity is a pattern of individual organ longevity,” says Thomas.
When it comes to living fast, plants generally have nothing on animals. That may be why animals rarely manage more than a few centuries before they die. There’s one exception: colonial animals like corals can survive for more than 4000 years. However, the individual coral polyps may be only a few years old.
Ming the mollusc is the oldest verified solitary animal on record. This ocean quahog was 507 years old when biologists dredged it up from the coastal waters around Iceland in 2006, and promptly killed it.
Ming died, but it might have been biologically immortal. In many animal cells, oxygen-containing molecules react with the membranes, generating small molecules that in turn damage other parts of the cell.
Not all animals carry a nice convenient record of their age around with them
But a 2012 study found that ocean quahog cells carry membranes that are unusually resistant to this sort of damage. Ming might have lived so long because its cells, like the cells of bristlecone pine, aged at a negligible rate.
Ming is the oldest animal with an age that can be verified. It’s a mollusc, so biologists can count annual growth lines in its shell, much as botanists can age trees by counting rings in the trunk.
Not all animals carry a nice convenient record of their age around with them. Some of these might be even older than Ming.
ake the Hydra, a tiny soft-bodied animal related to jellyfish. Small animals generally don’t live as long as large ones, but one biologist has kept individual Hydra in the lab for more than four years. That’s an astonishingly long time for an animal that generally measures just 15mm.
Perhaps a few years is about all most manage before succumbing
What’s more, at the end of the four-year experiment the Hydra looked as youthful as on day one. That makes Hydra another case of biological immortality.
Exactly how long individual Hydra might live is anyone’s guess. Perhaps a few years is about all most manage before succumbing to threats like disease. Or perhaps Hydra can live for 10,000 years.
A few years ago Bosch and his colleagues offered an explanation for Hydra’s lack of cellular ageing. Put simply, he says, it again comes down to stem cells.